|Title||Borazine-CF3- Adducts for Rapid, Room Temperature, and Broad Scope Trifluoromethylation.|
|Publication Type||Journal Article|
|Year of Publication||2018|
|Authors||Geri JB, Wolfe MMWade, Szymczak NK|
|Journal||Angew Chem Int Ed Engl|
|Date Published||2018 01 26|
A fluoroform-derived borazine CF3- transfer reagent is used to effect rapid nucleophilic reactions in the absence of additives, within minutes at 25 °C. Inorganic electrophiles spanning seven groups of the periodic table can be trifluoromethylated in high yield, including transition metals used for catalytic trifluoromethylation. Organic electrophiles included (hetero)arenes, enabling C-H and C-X trifluoromethylation reactions. Mechanistic analysis supports a dissociative mechanism for CF3- transfer, and cation modification afforded a reagent with enhanced stability.
|Alternate Journal||Angew Chem Int Ed Engl|