|Title||Difluoromethane as a precursor to difluoromethyl borates.|
|Publication Type||Journal Article|
|Year of Publication||2019|
|Authors||Geri JB, Aguilera EY, Szymczak NK|
|Journal||Chem Commun (Camb)|
|Date Published||2019 Apr 25|
Difluoromethane (CF2H2) is an ecologically-friendly refrigerant which holds promise as a source of CF2H-. However, the weak acidity (pKa = 35-41) and low stability of the conjugate base have prevented its utilization as a chemical feedstock. In this manuscript, we use a Lewis pair approach to deprotonate CF2H2 and capture CF2H- as R3B-CF2H- adducts. One reagent can be used as a base-free Suzuki reagent in palladium-mediated difluoromethylation, where CF2H- transfer is templated by precoordination to an azaborine derived R3B-CF2H- reagent.
|Alternate Journal||Chem Commun (Camb)|